Binding of Isaac DB

Challenges in Repentance

All 45 special challenge runs — starting loadout, goal floor, and unlocks.

Pitch Black

Challenge #1Rebirth
Goal floor
Burning Basement

High Brow

Challenge #2Rebirth
Goal floor
Burning Basement

Head Trauma

Challenge #3Rebirth
Goal floor
Burning Basement

Darkness Falls

Challenge #4Rebirth
Character
Eve
Goal floor
Catacombs
No alt path
Unlocks

You unlocked "Eve"

"It Lives!" Your futures past waits

"Sacrificial Dagger" has appeared in the basement

The Tank

Challenge #5Rebirth
Character
Magdalene
Goal floor
Burning Basement
Unlocks

You unlocked "Magdalene"

Solar System

Challenge #6Rebirth
Goal floor
Caves
No shooting
Unlocks

"A Noose" has appeared in the basement

Suicide King

Challenge #7Rebirth
Character
Lazarus
Goal floor
Catacombs
Alt path
Unlocks

You unlocked "Lazarus"

"It Lives!" Your futures past waits

Cat Got Your Tongue

Challenge #8Rebirth
Goal floor
Burning Basement
Black hearts
6
Soul hearts
6
No shooting
Unlocks

"Guppy's Hairball" has appeared in the basement

Demo Man

Challenge #9Rebirth
Goal floor
Caves
Unlocks

"A Fetus in a Jar" has appeared in the basement

Cursed!

Challenge #10Rebirth
Character
Magdalene
Goal floor
Burning Basement
Unlocks

You unlocked "Magdalene"

Glass Cannon

Challenge #11Rebirth
Character
Judas
Goal floor
Catacombs
No alt path
Starting loadout
Epic FetusLoki's Horns
Unlocks

"Loki's Horns" has appeared in the basement

"Epic Fetus" has appeared in the basement

"It Lives!" Your futures past waits

You unlocked "Judas"

When Life Gives You Lemons

Challenge #12Rebirth
Goal floor
Burning Basement
Starting loadout
Lemon MishapHabit9 VoltLemon Party

BEANS!

Challenge #13Rebirth
Goal floor
Burning Basement
No shooting

Its In The Cards

Challenge #14Rebirth
Goal floor
Burning Basement

Slow Roll

Challenge #15Rebirth
Goal floor
Burning Basement
Max damageMin shot speed

Computer Savy

Challenge #16Rebirth
Goal floor
Burning Basement

WAKA WAKA

Challenge #17Rebirth
Goal floor
Burning Basement

The Host

Challenge #18Rebirth
Goal floor
Burning Basement

The Family Man

Challenge #19Rebirth
Goal floor
Catacombs
No shootingAlt path
Unlocks

"It Lives!" Your futures past waits

"Dad's Key" has appeared in the basement

Purist

Challenge #20Rebirth
Goal floor
Caves
Unlocks

You unlocked "The Womb" -Chapter 4- Mother sleeps

XXXXXXXXL

Challenge #21Afterbirth
Goal floor
Caves
Unlocks

You unlocked "The Womb" -Chapter 4- Mother sleeps

SPEED!

Challenge #22Afterbirth
Goal floor
Caves
Unlocks

You unlocked "The Womb" -Chapter 4- Mother sleeps

Blue Bomber

Challenge #23Afterbirth
Character
???
Goal floor
Catacombs
No shootingNo alt path
Unlocks

"Mr. Mega!" has appeared in the basement

"It Lives!" Your futures past waits

PAY TO PLAY

Challenge #24Afterbirth
Goal floor
Catacombs
Alt path
Unlocks

"Mr. Mega!" has appeared in the basement

"A Bag of Pennies" has appeared in the basement

Have a heart

Challenge #25Afterbirth
Goal floor
Caves
Starting loadout
Charm of the Vampire
Unlocks

You unlocked "The Womb" -Chapter 4- Mother sleeps

I RULE!

Challenge #26Afterbirth
Goal floor
Flooded Caves
Unlocks

"Mom's Knife" has appeared in the basement

"The Negative" has appeared in the basement

You unlocked "Apollyon"

BRAINS!

Challenge #27Afterbirth
Character
???
Goal floor
Flooded Caves
No shootingAlt path
Unlocks

"The Polaroid" has appeared in the basement

PRIDE DAY!

Challenge #28Afterbirth
Goal floor
Caves
Unlocks

You unlocked "The Womb" -Chapter 4- Mother sleeps

Onan's Streak

Challenge #29Afterbirth
Character
Judas
Goal floor
Catacombs
Alt path
Starting loadout
Chocolate Milk
Unlocks

"It Lives!" Your futures past waits

You unlocked "Judas"

The Guardian

Challenge #30Afterbirth
Goal floor
Caves
No shooting
Unlocks

You unlocked "The Womb" -Chapter 4- Mother sleeps

Backasswards

Challenge #31Afterbirth+
Goal floor
Flooded Caves
Unlocks

"The Negative" has appeared in the basement

You unlocked "Apollyon"

Aprils fool

Challenge #32Afterbirth+
Goal floor
Caves
Unlocks

You unlocked "The Womb" -Chapter 4- Mother sleeps

Pokey mans

Challenge #33Afterbirth+
Goal floor
Catacombs
Alt path
Unlocks

"It Lives!" Your futures past waits

Ultra hard

Challenge #34Afterbirth+
Goal floor
Flooded Caves
Unlocks

"The Negative" has appeared in the basement

You unlocked "Apollyon"

PONG

Challenge #35Afterbirth+
Goal floor
Flooded Caves
Max damageAlt path
Unlocks

"The Polaroid" has appeared in the basement

Scat Man

Challenge #36Afterbirth+
Goal floor
Burning Basement
No shooting

Bloody Mary

Challenge #37Afterbirth+
Character
Bethany
Goal floor
Catacombs
No alt path
Unlocks

"It Lives!" Your futures past waits

"Blood Bag" has appeared in the basement

You unlocked "Bethany"

Baptism by Fire

Challenge #38Afterbirth+
Character
Bethany
Goal floor
Catacombs
No shootingAlt path
Unlocks

"It Lives!" Your futures past waits

"Maggy's Faith" has appeared in the basement

You unlocked "Bethany"

"Urn of Souls" has appeared in the basement

Isaac's Awakening

Challenge #39Afterbirth+
Goal floor
Caves
No alt path
Unlocks

You unlocked "Jacob&Esau"

Seeing Double

Challenge #40Afterbirth+
Character
Jacob
Goal floor
Caves
No alt path
Starting loadout
20/20
Unlocks

You unlocked "Jacob&Esau"

Pica Run

Challenge #41Afterbirth+
Goal floor
Catacombs
Alt path
Unlocks

"It Lives!" Your futures past waits

"Marbles" has appeared in the basement

Hot Potato

Challenge #42Afterbirth+
Character
Tainted The Forgotten
Goal floor
Catacombs
No shootingNo alt path
Unlocks

You unlocked "The Forgotten"

Cantripped!

Challenge #43Afterbirth+
Character
Tainted Cain
Goal floor
Burning Basement
No alt path
Unlocks

You unlocked "Cain"

Red Redemption

Challenge #44Afterbirth+
Character
Tainted Jacob
Goal floor
Caves
Starting loadout
Dad's Key
Unlocks

You unlocked "Jacob"

"Red Key" has appeared in the basement

Challenge #45Afterbirth+
Goal floor
Flooded Caves
Alt path
Starting loadout
TMTRAINER
Unlocks

You unlocked "Eden"